Nephropathology is a unique specialization in anatomic pathology, and a complete set of analyses comprising LM, IF, and TEM should always be considered. When performing a renal biopsy, few criteria should be encountered. First, the biopsy should be considered a procedure to improve therapy, and the biopsy should be done safely. An expert and specialized neuropathologist should evaluate the tissue sample to get the most informative description using all the methods required to characterize the pathological changes. The required methods for renal biopsy evaluation include special staining protocols for light microscopic (LM) evaluation, as well as for transmission electron microscopic (TEM) and immunofluorescence evaluations (IF).